Scott Weingart has put out a great EMCrit Podcast on the treatment and diagnosis of Thyroid Storm. With thyrotoxicosis and thyroid storm being relatively rare diseases, wiki page highlights the treatment and diagnosis. The severity of hyperthyroidism, thyrotoxicosis and thyroid storm can be assessed with the Burch-Wartofsky score. Treatment is focused on: Aggressive supportive care and early propranolol administration to decrease peripheral hormone conversion and decrease sympathetic surge. Also along with propranolol, thionamide administration (specifically PTU) blocks new hormone synthesis. Iodide can be administered afterwards to prevent further hormone production.