N-acetylcysteine is a well established and effective treatment for acetaminophen overdoses. The 21hr IV dosing and the 72hr oral regimens are also well studied and effective in preventing hepatic damage. One often over-looked technical detail to administration of NAC occurs with pediatric patients. There is a require dilution that is weight based for children that helps prevent electrolyte and fluid complications. The manufacturer provides a weight based dosing for pediatric patients.