The diagnosis formerly known as ALTE

The AAP has formally changed the name of ALTE to Brief Unexplained Event (BRUE). The definition has also been formalized with more specific criteria and suggestions to empower the clinician to base the diagnosis on their suspicion rather than relying only on the caregiver’s history.

BRUE is an event occurring in an infant <1 year of age when an observer reports a sudden, brief (<1 min), and now resolved episode of ≥1 of the following without explanation:

  • Cyanosis or pallor
  • Absent, decreased, or irregular breathing
  • Marked change in tone (hyper- or hypotonia)
  • Altered level of responsiveness
  • Must have returned to baseline

One thought on “The diagnosis formerly known as ALTE

  1. Not a good name – almost certainly some persons will pronounce this as “brew-ee” leading to confusion.

    The new emphasis and definition is well done and welcome.

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